Bone Matrix Formation Marker. Prices, Reviews, Ratings
General information
The P1NP marker will allow you to judge the speed and direction of bone metabolism processes. The level of P1NP in the blood is higher at night.
The organic matrix (base) of the bone is represented mainly by type 1 collagen, which is formed from type 1 procollagen synthesized by fibroblasts and osteoblasts. The N-terminal propeptide of procollagen 1 is released into the intercellular space and bloodstream during the formation of collagen 1 and its incorporation into the bone matrix.
Procedure
Preparation
You must not eat for eight hours before the procedure. Emotional stress and physical activity should be completely excluded the day before the session. You must not smoke half an hour before the test.
Bone matrix formation marker procedure
The procedure involves taking blood from a vein. The serum remains stable for 7 days at 2–8 °C. Avoid thawing and refreezing twice. It is recommended to conduct the study before the start of therapy and then at intervals of three months from its start.
Indications
The event is indicated:
- Before the start of osteoporosis therapy.
- When examining patients with Paget's disease, osteoporosis.
- To assess the effectiveness of anabolic and antiresorptive therapy.
Decoding the analysis
Reference values for women are:
- up to one month. – from 770 to 3203 ng/ml;
- from 1 month up to 1 year – from 560 to 2165 ng/ml;
- from 1 to 10 years – from 184 to 1024 ng/ml;
- from 10 to 13 years – from 192 to 1071 ng/ml;
- from 13 to 14 years – from 136 to 668 ng/ml;
- from 14 to 15 years – from 116 to 490 ng/ml;
- from 15 to 17 years – from 54 to 282 ng/ml;
- from 17 to 19 years – from 41 to 140 ng/ml;
- over 19 years – from 8 up to 80 ng/ml.
For men:
- up to 1 month – from 770 to 3203 ng/ml;
- from 1 month. up to 1 year - from 560 to 2165 ng/ml;
- from 1 to 10 years – from 184 to 1024 ng/ml;
- from 10 to 12 years – from 237 to 635 ng/ml;
- from 12 to 15 years – from 202 to 1212 ng/ml;
- from 15 to 16 years – from 223 to 883 ng/ml;
- from 16 to 17 years – from 148 to 1080 ng/ml;
- from 17 to 18 years – from 113 to 538 ng/ml;
- from 18 to 24 years old – from 40.5 to 107.4 ng/ml;
- from 24 to 30 years old – from 22.5 to 120 ng/ml;
- over 30 years old – from 10.2 to 95 ng/ml.
Elevated level:
- osteoporosis;
- osteomalacia;
- osteogenesis imperfecta;
- Paget's disease;
- renal osteodystrophy;
- metastatic bone lesions.
The P1NP level should be assessed taking into account the indicators of tissue resorption and remodeling in dynamics. An increase in P1NP during antiresorptive therapy indicates the effectiveness of treatment measures.
The results in patients with impaired renal function should be interpreted with caution, since there may be a decrease in the excretion of the marker in the urine and, consequently, an increase in its level in the serum.
Prices and clinics
The service is provided by a qualified endocrinologist in private and public clinics. You can find out more detailed information on the medical portal .
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