Chlamydia IgA (Chlamydia trachomatis). Prices, Reviews, Ratings
The invasive disease caused by the pathogenic bacteria Chlamydia trachomatis (CT) is called chlamydia.
The invasive disease caused by the pathogenic bacteria Chlamydia trachomatis (CT) is called chlamydia.
Infection typically occurs via sexual contact with an infected partner. Chlamydial bacteria cause pathological conditions including urogenital diseases, certain arthritides, trachoma, conjunctivitis, and neonatal pneumonia. They exert virulent (affecting vascular endothelium, lymph nodes, lung tissue, conjunctiva, and genital mucosa) and toxigenic (releasing endotoxins causing bleeding) effects. Their outer membranes’ antigenic properties trigger host immunocompetent cell sensitization, producing antibodies (Abs) of various classes (IgM, IgA, IgG).
Indications for Chlamydia IgA Testing
Changes in cellular and humoral immune segments during Chlamydia invasion stimulate production of multiple immunoglobulins against CT antigens. The initial protective response involves IgA induction in secretions, then blood serum.
Detecting IgA is a specific marker of active infection in clinical practice, appearing in serum 10–15 days post-infection. Successful treatment reduces levels within 60–120 days, while reinfection increases them.
IgA detection, with production dynamics, confirms the pathogen’s presence and aids in staging the disease. Persistent levels post-therapy suggest treatment failure and chronicity risk.
How Is Chlamydia IgA Testing Conducted?
Anti-chlamydial IgA detection uses test systems with ELISA, IIF, and IHA methods.
A specialist draws venous blood, and serum is obtained by centrifugation. Testing stages:
- Incubation-1: Patient serum is mixed with sensitized Chlamydia antigen on a plate and held at a set temperature to bind with CT antibodies (forming an Ag-Ab complex).
- Washing-1: Removal of unbound non-specific globulins.
- Incubation-2: The Ag-Ab complex is thermostated with enzyme-labeled anti-IgA serum.
- Washing-2: Removal of unbound labeled antibodies.
- Enzymatic reaction produces a colored product, its intensity reflecting specific IgA antibody complex levels in the test mixture and patient sample.
Fluorescence and agglutination methods vary slightly but maintain the same identification principle.
IgA titer ranges for Chlamydia trachomatis stages: initial (acute) – 50–1600, chronic – <50, reinfection – 55–400, post-recovery – ≤50.
Completion Time for Chlamydia IgA Testing
The straightforward ELISA method, with trained staff and modern lab equipment, yields results in 90–120 minutes.
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