Anti-Giardia Antibodies (Total IgA, IgM, IgG Detection). Prices, Reviews, Ratings
One of the most common protozoal human diseases is giardiasis. Its causative agent is the flagellated protozoan Lamblia Intestinalis (LI) or Giardia Lamblia (GL). Transmission occurs via the fecal-oral route, primarily affecting the small intestine and causing ~20% of acute intestinal pathologies. GL colony accumulation in the intestinal mucosa triggers an immune response, producing antibodies (IgM, A, G), sensitizing immunocompetent cells to neutralize and eliminate the pathogen.
One of the most common protozoal human diseases is giardiasis. Its causative agent is the flagellated protozoan Lamblia Intestinalis (LI) or Giardia Lamblia (GL). Transmission occurs via the fecal-oral route, primarily affecting the small intestine and causing ~20% of acute intestinal pathologies. GL colony accumulation in the intestinal mucosa triggers an immune response, producing antibodies (IgM, A, G), sensitizing immunocompetent cells to neutralize and eliminate the pathogen.
Indications for Detecting Anti-Giardia Antibodies
Clinical indications include digestive tract damage with chronic tendencies, frequent exacerbations, allergic reactions, and eosinophilia.
LI invasion features diverse clinical manifestations without specific symptoms, requiring multiple lab tests. Key tests include cyst detection via coproscopy and vegetative forms (trophozoites) in duodenal contents.
Serum testing for LI antigen antibodies enhances diagnostic accuracy. Antibody levels depend on infection intensity, disease progression, and patient immune protection, persisting throughout LI invasion stages. These serological tests aid diagnosis and epidemiological monitoring.
Giardiasis-causing parasites negatively impact the host’s immune system, ensuring survival by synthesizing proteases that degrade immunoglobulins.
How Anti-Giardia Antibody Detection Is Conducted
In infected individuals, antibodies are represented by three immunoglobulin classes. IgM is detectable in serum by days 10-15 post-infection, followed by other globulin types, which drop sharply months after GL elimination. This immunodynamic specificity enables disease identification and stage differentiation.
The enzyme-linked immunosorbent assay (ELISA) with test kits and automated analyzers is used, typically with venous blood. Testing detects two antibody factors in serum: IgM (IM) and total antibodies (SAT) of all three types (M, G, A).
Result interpretation:
- No factors detected – another infection is present;
- IM present, SAT absent – acute (initial) LI invasion;
- Both present – acute stage transitioning to chronic or exacerbation;
- IM absent, SAT present – chronic course or past infection.
This method effectively monitors giardiasis therapy.
Turnaround Time for Anti-Giardia Antibody Testing
With modern automated analyzers, testing takes about 2 hours.
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