LDH (Lactate Dehydrogenase). Prices, Reviews, Ratings
Lactate Dehydrogenase (LDH) is an enzyme that facilitates the conversion of lactate (lactic acid) to pyruvate (PVA). This substance actively participates in glycolysis.
Lactate Dehydrogenase (LDH) is an enzyme that facilitates the conversion of lactate (lactic acid) to pyruvate (PVA). This substance actively participates in glycolysis.
LDH concentration varies by age: higher in infants than in the elderly.
This biocatalyst increases activity under circumstances like:
- Post-exercise or other physical exertion;
- During pregnancy.
In diseases involving tissue trauma and cell damage, blood LDH levels rise, leading to the breakdown of vital substances.
Indications for Lactate Dehydrogenase (LDH) Level Testing
This test is conducted to diagnose:
- Anemia (chlorosis);
- Pulmonary infarction;
- Myocardial infarction;
- Liver damage;
- Leukemia;
- Myeloleukemia.
Comprehensive patient testing detects conditions with erythrocyte hemolysis, kidney, and muscle tissue pathologies. Elevated serum lactic dehydrogenase activity occurs in anemia (hemolytic, pernicious, sickle-cell, megaloblastic).
The glycolytic enzyme increases in density with malignant tumors, making LDH testing common for suspected oncopathology.
It is mandatory during patient dispensary evaluations.
LDH is most active in conditions like:
- Anemia;
- Hepatitis;
- Myocardial infarction;
- Cirrhosis;
- Cancer.
Testing is essential for these suspected conditions.
How Lactate Dehydrogenase (LDH) Level Testing Is Conducted
Lab technicians use a kinetic method based on the chemical reaction rate’s dependence on substance concentration. Avoid eating 12 hours before, limit physical exertion, and refrain from smoking 30 minutes prior. Alcohol is strictly prohibited, and medication use should be minimized.
A specialist draws venous blood, placing it in a vacutainer with an anticoagulant or gel. The puncture site is pressed with a cotton ball to stop bleeding; warm compresses are prescribed for hematomas.
For suspected myocardial infarction, testing is repeated thrice. Avoid serum hemolysis to prevent inaccurate results.
Reference values:
- Children up to 4 days – 1775 U/L;
- 4-10 days – 2000 U/L;
- 10 days – 2 years – 430 U/L;
- 2-10 years – 295 U/L;
- Adults over 12 – 250 U/L.
A cardiologist, therapist, or oncologist orders this test.
Turnaround Time for LDH Level Testing
Results are typically ready the next day, with express analysis available within hours.
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