Anti-Erythrocyte Antibodies. Prices, Reviews, Ratings
Many people, regardless of race, nationality, gender, or occupation, have anti-erythrocyte antibodies (AEA) in their blood. Their origins vary: post-transfusion of erythrocyte-containing components, pregnancy, exposure to antigen-containing sources, gene mutations affecting immunoglobulin function/specificity, maternal antibody transfer via the placenta, or sensitization during sexual contact.
Many people, regardless of race, nationality, gender, or occupation, have anti-erythrocyte antibodies (AEA) in their blood. Their origins vary: post-transfusion of erythrocyte-containing components, pregnancy, exposure to antigen-containing sources, gene mutations affecting immunoglobulin function/specificity, maternal antibody transfer via the placenta, or sensitization during sexual contact.
Indications for Detecting Anti-Erythrocyte Antibodies
Most transfusion complications stem from incompatible erythrocyte-containing biocomponents, highlighting immune factors’ significance.
Allosensitization occurs when the body produces alloimmune antibodies against antigens absent in the individual. Recipient alloantibodies against donor antigens reduce transfused erythrocyte survival and function.
Testing donors, recipients, and pregnant women for AEA is mandatory to prevent post-transfusion complications, ensuring safe transfusion therapy, managing pregnancy, and treating neonatal hemolytic conditions.
How Anti-Erythrocyte Antibody Detection Is Conducted
Testing occurs in two stages: screening for antibody presence/absence, then determining specificity of detected AEAs across systems like ABO, Rh, Lewis (LE), Duffy (FY), Kidd (JK), Lutheran (LU), Kell-Cellano (KC), and MNS (MNSS).
Main detection methods:
- Salt medium specific agglutination – ideal for ABO, Rh, and Lewis;
- 33% polyglucin express method – requires high antibody titers;
- 10% gelatin conglutination – effective for all except Duffy, Kidd, and MNS, even with low titers;
- Antiglobulin – informative for all except ABO and MNS;
- Gel test – combines agglutination and gel filtration, highly sensitive with quality control, yielding quick results; with antiglobulin, detects all types.
Alloantibody identification success depends on serum titer, specificity, form (complete/incomplete), and appropriate methodology.
Turnaround Time for Anti-Erythrocyte Antibody Testing
Time varies (15-55 minutes) based on method and biomaterial preparation technique.
Prices and Clinics
Accurate interpretation ensures conflict-free donor selection, a critical task for highly qualified specialists. Choose a diagnostic center via the medical portal, reviewing clinic details and booking appointments online or by phone.
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