Category Archives: Medicina

Medicine

ORIGINAL ARTICLE: K-ras Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer

Posted on October 22, 2008 by Karapetis, C. S., Khambata-Ford, S., Jonker, D. J., O'Callaghan, C. J., Tu, D., Tebbutt, N. C., Simes, R. J., Chalchal, H., Shapiro, J. D., Robitaille, S., Price, T. J., Shepherd, L., Au, H.-J., Langer, C., Moore, M. J., Zalcberg, J. R.

This study examined the mutation status of the K-ras gene in colorectal tumors from patients who were enrolled in a trial of cetuximab, a monoclonal antibody against the epidermal growth factor receptor (EGFR). A survival benefit was found among patients with tumors bearing wild-type K-ras but not among patients with tumors bearing mutated K-ras. Wild-type K-ras is essential in transmitting signals initiated by EGFR.

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PERSPECTIVE: Election 2008: Three “Inconvenient Truths” about Health Care

Posted on October 22, 2008 by Fuchs, V. R.

A strong case for comprehensive reform of the U.S. health care system has been made many times. The high cost of care, the large number of uninsured people, and the … Continue reading →

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Sacconi: serve imparzialità sugli OGM

Posted on October 22, 2008 by MolecularLab.it - News di Scienza, Ricerca, Biotech, Medicina e Biologia Molecolare
Secondo il ministro del Lavoro della Salute e delle Politiche sociali, Maurizio Sacconi, l'Italia dovrebbe sbloccare l'attuale situazione degli OGM, soggetti al momento ad una “moratoria di fatto”. Sarebbe questa una politica da attuare “senza rinunciare alle caratteristiche della produzione qualitativa e tradizionale che merita sempre etichettature trasparenti che la facciano riconoscere … (leggi »)
in Analisi e Commenti


Tag: OGM sondaggio coltivazioni
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Computer biologici per la farmacologia

Posted on October 22, 2008 by MolecularLab.it - News di Scienza, Ricerca, Biotech, Medicina e Biologia Molecolare
Al California Institute of Technology (CalTech) si studia la possibilità di funzionamento di veri e propri computer biologici, che permettano di comunicare con i sistemi viventi a livello micromolecolare.
L'RNA, acido nucleico simile al DNA da cui differisce solo per la presenza di un atomo di ossigeno nelle sue componenti zuccherine, è lo strumento con cui i ricercatori si sono … (leggi »)
in Genetica, Biologia Molecolare e Microbiologia


Tag: computer RNA
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EARLY RELEASE: Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma

Posted on October 15, 2008 by Bouzigon, E., Corda, E., Aschard, H., Dizier, M.-H., Boland, A., Bousquet, J., Chateigner, N., Gormand, F., Just, J., Le Moual, N., Scheinmann, P., Siroux, V., Vervloet, D., Zelenika, D., Pin, I., Kauffmann, F., Lathrop, M., Demenais, F.

Background A genomewide association study has shown an association between variants at chromosome 17q21 and an increased risk of asthma. To elucidate the relationship between this locus and disease, we … Continue reading →

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EARLY RELEASE: Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

Posted on October 15, 2008 by Hoshida, Y., Villanueva, A., Kobayashi, M., Peix, J., Chiang, D. Y., Camargo, A., Gupta, S., Moore, J., Wrobel, M. J., Lerner, J., Reich, M., Chan, J. A., Glickman, J. N., Ikeda, K., Hashimoto, M., Watanabe, G., Daidone, M. G., Roayaie, S., Schwartz,

Background It is a challenge to identify patients who, after undergoing potentially curative treatment for hepatocellular carcinoma, are at greatest risk for recurrence. Such high-risk patients could receive novel interventional … Continue reading →

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EARLY RELEASE: Recurrence of Hepatocellular Carcinoma

Posted on October 15, 2008 by Sherman, M.

(No abstract is available for this citation) Continue reading →

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EARLY RELEASE: 17q21 Variants and Asthma — Questions and Answers

Posted on October 15, 2008 by Holloway, J. W., Koppelman, G. H.

(No abstract is available for this citation) Continue reading →

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EARLY RELEASE: GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes

Posted on October 8, 2008 by Ludvigsson, J., Faresjo, M., Hjorth, M., Axelsson, S., Cheramy, M., Pihl, M., Vaarala, O., Forsander, G., Ivarsson, S., Johansson, C., Lindh, A., Nilsson, N.-O., Aman, J., Ortqvist, E., Zerhouni, P., Casas, R.

Background The 65-kD isoform of glutamic acid decarboxylase (GAD) is a major autoantigen in patients with type 1 diabetes mellitus. This trial assessed the ability of alum-formulated GAD (GAD-alum) to … Continue reading →

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EARLY RELEASE: Immunotherapy on Trial for New-Onset Type 1 Diabetes

Posted on October 8, 2008 by Faustman, D. L.

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